What Not to Mix with Vitamin C Serum (And What Works Best)

Vitamin C is powerful—but it’s not always compatible with every ingredient in your routine. Here’s what to avoid and what pairs well with it.

Ingredients to Avoid Mixing with Vitamin C:

• Retinol: Can cause irritation when layered together.

• Benzoyl Peroxide: May deactivate Vitamin C.

• AHAs/BHAs: Using too many exfoliants can over-sensitize skin.

Ingredients That Work Well With Vitamin C:

• Hyaluronic Acid: Boosts hydration and soothes skin.

• Niacinamide (if well-formulated): Can brighten and balance.

• SPF: Essential to protect your skin after applying Vitamin C.

Pro Tip: If you want to use Vitamin C and Retinol, apply Vitamin C in the morning and Retinol at night.